McLean scientists link abnormalities in circadian rhythms to specific neurochemical changes in the brains of people with bipolar disorder that coincide with increased severity of symptoms in the morning. Kemal Ataturk (Mustapha Kemal) modernized the nation by adopting a new code of laws, by making civil marriage compulsory, and by abolishing the fez for men and the veil for women, he also abandoned the lunar calendar of Islam and adopted he solar calendar of the West. Every week we'll be bringing you one-off documentaries and series from the world's top broadcasters, including the BBC, Channel 4, Discovery and PBS. Herodotus described the Tower of Babel as a pile of solid towers, each slightly smaller than the one on which it rested. Eye and Ear researchers discover VEGF, a molecule implicated in diabetic retinopathy and age-related macular degeneration, the most common forms of blindness. Boston, MA 02115
The volume is divided into four books: Time, The Earth and the Seas, Nature, and Society. Her DNA is identical to the sheep she was cloned from. Concurrently, French physicist, Antoine-Henri Becquerel . Our summaries and analyses are written by experts, and your questions are answered by real teachers. 1958), Learn how and when to remove this template message, The Nine Chapters on the Mathematical Art, Philosophical Transactions of the Royal Society, Universal Natural History and Theory of Heaven, Breakthrough of the Year Breakthrough of the Year, first ever image of a black hole was captured, "In Search of the Earliest Balance Weights, Scales and Weighing Systems from the East Mediterranean, the Near and Middle East", "A Navigational Instrument of the Harappan Sailors", "A Geometric Algorithm with Solutions to Quadratic Equations in a Sumerian Juridical Document from Ur III Umma", "Ancient times table hidden in Chinese bamboo strips", "Quelques textes mathmatiques de la Mission de Suse", "Webpage cites AN INTRODUCTION TO THE HISTORY OF MATHEMATICS", "An Ancient Greek Philosopher Was Exiled for Claiming the Moon Was a Rock, Not a God", "The Adaptation of Babylonian Methods in Greek Numerical Astronomy". Brigham and Womens researchers discover that a protein (amyloid beta) thought to be an early, causative feature of Alzheimer's disease is also present in healthy individuals and that patients with Alzheimer's produce too much of this protein or cannot break it down properly. He sailed from Iceland again, this time with an emigrant fleet of twenty-five ships carrying men and women and domestic animals. History Timeline! 1820 Quinine first purified from tree bark. Much of the space in this section is devoted to the development of the clock, from hourglasses and water clocks to sophisticated mechanical timepieces. Dante Alighieri. When Gomes contract expired, the King gave the trading rights to his own son, John, who became King John II, opening the next great age of Portuguese seafaring. Tancred was a Norman who led the First Crusade, captured Jerusalem, and then established still another kind of Norman kingdom in Syria. The jury in the case found Murdaugh guilty of the murders when they returned their verdict on 2 March. London announced the declaration of war against Spain. He claimed that all the planets, including Earth, moved in orbits around the sun, and showed how this new system could accurately . . HMS Cell Biology researchers discover necroptosis and its inhibition by small-molecule inhibitors of RIPK1, which leads to clinical studies of RIPK1 inhibitors as potential therapies for amyotrophic lateral sclerosis (ALS) and Alzheimers disease. The structure of diphtheria toxin structureis discovered, which leads to the discovery of a safer, more economical vaccine. Martin Kelly, M.A., is a history teacher and curriculum developer. Timeline Of Nasa. 1524: In a French-sponsored voyage,Italian explorerGiovanni de Verrazzano (14851528) discovers the Hudson River before sailing north to Nova Scotia. 617-432-1000, 2023 by The President and Fellows of Harvard College, Insect-borne disease transmission; scurvy; heat-killed vaccines, Insulin; founding of Joslin Diabetes Center, Overactive thyroid; rickets; osteoporosis, Burn treatment; blood bank; emergency-response plans, Artificial kidney; pediatric remission of acute luekemia, Vaccine culture technique; cortisone; White classification, Platelets; proton beam therapy; implantable cardiac pacemaker, Human limb reattachment; heart rhythm restoration, Human oncogene; positron emission tomography (PET) scan, Artificial skin; premature puberty reversal, Congenital birthmark treatment; Huntington's disease, Kawasaki disease retrovirus; Alzheimer's disease, Early-onset Alzheimer's gene; Duchenne muscular dystrophy gene, Neovascular macular degeneration; microRNAs; paralyzed vocal cord surgical method; colon cancer gene; VEGF molecule, Triple-organ transplant; kidney disease blood glucose levels, How cells sense oxygen; Alzheimer's treatments; immune system advances, Brain abnormalities associated with abuse and neglect, Rheumatoid arthritis pathway; C-reactive protien, Multidrug-resistant tuberculosis treatment; source of preeclampsia, Prenatal nutrition; herpes vaccine candidate, Cholesterol mechanism; DNA sequencing techniques, Cellular switch; rheumatoid arthritis gene; brown-fat cell switch, RIPKI inhibitors; metastatic melanoma remission, LIN28 protien; RNA interference; cancer cells' starvation; brown fat, Kidney failure markers; cancer cell vulnerability; global health care budget models, Tumor suppressor gene p53; ancient migration; infectious disease diagnostics, Cardiac hypertrophy reversal; cathepsin k pathways, Hematopoietic stem cells; pancreatic stem cells, Bioartificial replacement limb; PD-1 pathway; The Lancet Commission on Global Surgery; pseudogene; damaged protein disposal; multiple sclerosis; somatic mutations; deafness gene therapies, Sigma-1 receptor structure; Zika vaccine candidate; circadian rhythm-bipolar disorder link; microbiome, Unlocking the blood-brain barrier; deciphering the structure of a scissorlike enzyme, The 'graying' of T cells; From one cell, a detailed roadmap, Finding herpes' Achilles' heel; viral peptides critical to natural HIV control, Research Departments, Centers, Initiatives and more, Celebrating 50 Years of Diversity and Inclusion, Harvard COVID-19 Information: Keep Harvard Healthy, Learn more about research at HMS on the Quad and beyond, More information about recent discoveries at the Schools 15 affiliates. In search of a way to measure the cycle of the seasons in multiples of moon cycles, they eventually discovered the so-called metonic cycle (after and astronomer Meton) of nineteen years. The Portuguese and Spanish played a particularly important role in the Age of Discovery, but as time went on, other European countries began making contributions as well. Judah Folkman and his research team at Boston Childrens produce a synthetic compound that inhibits the growth of blood vessels associated with tumors. The Scientific Revolution occurs in Europe around this period, greatly accelerating the progress of science and contributing to the rationalization of the natural sciences. - 51 B.C. Traditionally, the age of exploration in America begins in 1492 with the first voyage of Christopher Columbus. Cambodian king Suryavarman built the the most gigantic religious monument in the world of the stupa temple complex of Angkor Wat. Centriole - Discovered by Edouard Van Beneden in 1883 and was described and coined by Theodor . Central & Southern Africa & the Indian Ocean Economy, Great Explorers of Spain and Portugal: Aims & Discoveries, How International Trade Changed in the Age of Exploration, American Revolution Battles: Lesson for Kids, European Exploration in India & Southeast Asia, Vasco Da Gama Lesson for Kids: Facts & Biography, Hernando de Soto Lesson for Kids: Facts & Biography, Christopher Columbus Lesson for Kids: Ships & Voyages, European Motivations for Exploration & Trade: Lesson for Kids, Life in the Southern Colonies Lesson for Kids, Yuan Dynasty: Social Structure, Economy & Trade, John Cabot Lesson for Kids: Facts & Biography, SAT Subject Test US History: Practice and Study Guide, High School World History: Help and Review, AP European History: Homeschool Curriculum, Important People in World History Study Guide, MTTC Social Studies (Secondary) (084) Prep, Praxis Social Studies: Content Knowledge (5081) Prep, ILTS Social Science - History (246): Test Practice and Study Guide, NY Regents Exam - US History and Government: Test Prep & Practice, NY Regents Exam - Global History and Geography: Test Prep & Practice, High School World History: Homework Help Resource, High School World History: Tutoring Solution, Create an account to start this course today. Beth Israel Deaconess researchers pinpoint the source of preeclampsia, a life-threatening complication of pregnancy and one of the leading causes of maternal and infant mortality worldwide. and the oldest existing sample from that era was from 6,000 B.C.E. US History Timeline: The Dates of America's Journey. This begins with the heliocentric system of Copernicus who, Boorstin points out, was a contemporary of Luther, Calvin, and Melanchthon, the prophets of Protestantism, anti-intellectuals who were hostile to his discoveries. When Baldaya went out again, with orders to bring back an inhabitant for the Prince to interview at Sagres, he reached what seemed to be the mouth of a huge river, which he hoped would be the Senegal of the silent trade in gold. In studies of the microbiome, HMS Microbiology and Immunobiology researchers find an array of individual bacterial species in the human gut that work together to influence immuno-inflammatory responses. As legend has it, he searches for the Fountain of Youth but doesn't find it. Book 1: TIME 00000 % complete "Time is the greatest innovator" - Francis Bacon(1625) Part 1:The Heavenly Empire The Temptations of the Moon Note. Morris R. Cohen and I. E. Drabkin (eds. The earliest verifiable eclipse reported by any people is recorded by the Chinese. More information about recent discoveries at the Schools 15 affiliates. Elliott Joslin becomes one of the first physicians to introduce insulin to the United States and subsequently founds Joslin Diabetes Center. Working at Joslin, William Beetham and Lloyd M. Aiello pioneer pan-retinal coagulation, a treatment that uses lasers to halt the sight-stealing proliferation of blood vessels in people with diabetes. Seven Kings of Rome History | Who was the Last King of Rome? He also examines the development of both astrology and astronomy, and explains how the former was discredited, as were other attempts at divination. When the Spanish Inquisitor - general Torquemada gave Jews three months to convert to Christianity or leave the country, the brilliant Abraham Zacuto left the University of Salamanca and was welcomed to Portugal by King John II. 2023 eNotes.com, Inc. All Rights Reserved. In this lesson, we will examine what is commonly called the Age of Discovery. Cortes conquered the Aztecs in Mexico, while Pizarro conquered the Incas in South America. THE DISCOVERERS is a charming, bittersweet comedy and moving debut feature from writer/director Justin Schwarz. B.L. Book Three (Nature) is concerned with the scientific investigation of nature. He explored along the St. Lawrence River in 1534. Benjamin Waterhouse introduces the smallpox vaccine to the United States and helps gain acceptance for the new procedure. Kelly, Martin. The roots of astrology begin with earliest civilization. ThoughtCo. He measures the circumference of the Earth. He is the author of "The Everything American Presidents Book" and "Colonial Life: Government. The Emperor of China ordered all observers in the imperial observatory to keep their business secret " Not to tell any common people about what they did for a living". Although the discovery of DNA occurred in 1869 by Swiss-born biochemist Fredrich Miescher, it took more . Helping women with diabetes who wish to have children, Joslin physician Priscilla White introduces the White classification of diabetic pregnancies, a widely used method to categorize patients risk and tailor treatments accordingly. Jack Szostak, HMS professor of genetics and the Alexander Rich Distinguished Investigator at Massachusetts General Hospital, co-discovers telomeres, regions of repetitive DNA that protect the ends of chromosomes and that shorten each time a cell divides. Mass General researchers contribute to the discovery of the first gene associated with inherited early-onset Alzheimers disease. c. 300 BC: Finite geometric progressions are studied by Euclid in Ptolemaic Egypt. Sept. 25 Dinner and ball. Start your 48-hour free trial to get access to more than 30,000 additional guides and more than 350,000 Homework Help questions answered by our experts. 1629- An Italian engineer and architect, Giovanni Branca, invented a steam turbine. The paper had a huge impact on Chargaff and changed the future course of his career. It was believed that such a planet had to exist in order to explain some odd things happening in the orbits of Uranus and Neptune. This same gene-finding technique later enables scientists to find genetic markers for other inherited diseases. 3rd century BC: Archimedes develops the field of statics, introducing notions such as the center of gravity, mechanical equilibrium, the study of levers, and hydrostatics. The Age of Discovery was a period of time between the 1400s and 1600s. In neurologic studies, Brigham and Womens researchers discover a gene variant that may help patients with multiple sclerosis better respond to a certain medication. An error occurred trying to load this video. "There is no sea in-navigable, no land uninhabitable", - Robert Thorne, Merchant and Geographer (1527). From Prince Henrys household went Nuno Tristo and Anto Gonalves, reaching another two hundred fifty miles farther to Cape Branco (Blanco) where they took two natives captive. They were wrong. These volumes remain . Timeline of Discovery. 1947 . Compasses. The last four elements to be discovered are nihonium, moscovium, tennessine, and oganesson. Even though Hooke discovered the cell he did not know of the structure . Theobald Smith identifies the mechanism of insect-borne disease transmission, discovers the cause of scurvy and develops the concept of heat-killed vaccines. If there are three dates, the first date is the date of the original Cell Membrane - Robert Hooke in 1665 first view the cells under the microscope and hence, he is credited with the discovery of cell membrane. Skip Navigation. Hipparchus discovered the procession of the equinoxes, cataloged 1,000 stars, and invented trigonometry. Throughout the 1400s, the Portuguese led the way in maritime exploration. The Strasbourg clock is rebuilt with movable feasts, a Copernican planetarium with revolution of the planets, phases of the moon, eclipses, apparent and sidereal times, procession of the equinoxes, and etc. In Book One (Time), Boorstin says that The first grand discovery was time, the landscape of experience. This discovery first allowed us to make measurements outside the cycles of nature. Mass General clinicians become the first to use proton beam therapy to treat tumors of the eye, neck and brain. In the book "Games at Twilight", what details do you notice that show this story is not taking place in the United States? X-ray applications are being used as early as January. Realizing the small neighboring country of Portugal was dominating exploration, Spain began sending out explorers of their own. A copy of Ptolemy in Greek was brought from Constantinople to Florence by Palla Strozzi. 12th century AD: Jewish polymath Baruch ben Malka in Iraq formulates a qualitative form of, 1517: Nicolaus Copernicus develops the quantity theory of money and states the earliest known form of. The first series of successful operations is performed at Peter Bent Brigham for repair of stenotic mitral heart valves. "Hipparchus' Treatment of Early Greek Astronomy: The Case of Eudoxus and the Length of Daytime Author(s)". Research into the development of insulin has driven scientists to take significant steps towards understanding human biology and a number of Nobel Prizes have been awarded for research into the hormone. Parliament passed an act " For providing a Publick Reward for such Person or Persons as shall discover the Longitude at Sea". Did It Supply the 5000 Stades Arc for Eratosthenes' Experiment?". Post-expedition 1806. Enrolling in a course lets you earn progress by passing quizzes and exams. The 19th Century. The final part of the book, The Infinite and the Infinitesimal, looks at the development of physics, with a particular focus on the atom (the infinitesimal) on one hand and the expansive nature of the universe (the infinite) on the other. To avoid overlap with timeline of historic inventions, the timeline does not list examples of documentation for manufactured substances and devices unless they reveal a more fundamental leap in the theoretical ideas in a field. Sources. Rheticus First Report (Narratio Prima) was printed in Danzig. The astonishing thing is that these discoveries were made at all. 2nd century BC: Hipparchos measures the sizes of and distances to the moon and sun. This finding may lead to a way to deliver drugs across the barrier and into the brain to treat disorders such as brain cancer, stroke and Alzheimers. Here is a timeline of events provided of when and how the classified documents were discovered: Nov. 2. In studies to combat the herpes simplex virus type 2, the most common form of genital herpes, David Knipe in HMS Microbiology and Immunobiology develops a replication-deficient vaccine called dl5-29, which stimulates the immune system from inside host cells, a quality other vaccines lack, and becomes a leading candidate in human vaccine trials. Digging Deeper. To call it a history of science is an understatement; this is the story of how humankind has come to know the world, however incompletely ("the eternal mystery of the world," Einstein once said, "is its comprehensibility"). 1535: French explorer Jacques Cartier (14911557) explores and maps the Gulf of Saint Lawrence. 3 billion BC : The origin of diamonds Diamonds are considered one of the oldest materials on earth: 1 to 3.5 billion years old. The Age of Discovery was a period of time between the 1400s and 1600s, when global exploration took place at an unprecedented level. CRISPR Timeline. In 6th century BC Greece, this knowledge is used to predict eclipses. 1678 - Van Leeuwenhoek views Bacteria. The antibiotics are coloured per their source: . The Circuit: Stories from the Life of a Migrant Child, The Landmark History of the American People. 1620 - Niccolo Cabeo discovers that electricity can be repulsive as well as attractive. 3rd century BC: Eratosthenes measures the circumference of the Earth. However, it's best to recognize that Columbus wasn't the first human to put a foot in the Americas. Around this same time, another Spanish explorer, Juan Ponce de Leon, explored Florida and became famous for his quest to find the Fountain of Youth. Bernard Lown becomes the first to use direct electric current to restore the rhythm of the heart. Led by Oscar- and Emmy-nominated Dunne's striking comeback performance, this heartfelt tale of family dysfunction and rediscovery features an award-winning ensemble, including Emmy Award-winner Stuart Margolin ("The Rockford Files . A 9th planet had been looked for for some time. In 1725 new diamond deposits were discovered in Brazil, and production was significantly enlarged. 1 language. Covering time, the earth and the seas, nature and society . The " Chinese Caesar" , King Cheng, managed within 25 years to unify a half-dozen Chinese provinces into a single great empire, with a vast hierarchy of bureaucrats. The Age of Exploration: Columbus (1492) to Eve of American Revolution . The campanile of the Chapel of the Blessed virgin in Milan is admired by Galvano della Fiamma. From its explorations of dark matter to its quest to determine the age of the universe, Hubble has helped answer some of the most compelling astronomical questions of our time, and . The colony collapses within a decade. Tycho Brahe, Kepler, and Galileo are also discussed, with particular emphasis on the development of the telescopeone of the few crucial inventions Boorstin regards as vital to the story he has to tell, along with the clock, the printing press, the microscope, and the compass. While some scholars argue it began in 1492, others point toward earlier dates. For many years prior, the ground bark had been used to treat malaria. Mass General clinicians pioneer telemedicine, the practice of medicine over closed-circuit television. With a grand gesture, instead of trying to sell his telescope, Galileo made it a gift to the Venetian Senate in a ceremony. It was first published in 1983 and is the first of a trilogy, being followed by The Creators and The Seekers. Japan was able to make mainsprings for spring driven clocks. 1799 Smallpox vaccine. Challenging a half century-old theory that chemotherapy works by targeting fast-dividing cells, Dana-Farber researchers report that cancer cells on the verge of self-destructing are especially vulnerable to chemotherapy. Timeline showing the decade new classes of antibiotic reached the clinic. William the Conqueror and his men set up the Kingdom of Sicily, where Christians, Jews and Arabs exchange knowledge, arts, and ideas. 72, pp. The life of the Chinese pioneer Chang Heng. So, I just want to make it easy for you all by jotting down the organelles and their discoverers over here. Rheticus wrote his First Report (Narratio Prima) of Copernicus system, in the form of a letter to his former teacher. Boston Childrens stem-cell researchers, led by George Q. Daley, find that LIN28, a protein abundant in embryonic stem cells, is aberrantly expressed in about 15 percent of all cancers, revealing a possible new target for drug development. It was first published in 1983 and is the first of a . This article presents a chronological timeline of key events that occurred during the Age of Discovery. What details do you notice that show that this story is not taking place in the United States? The American Institute of Chemical Engineers (AIChE) was established by a committee of chemists and engineers in 1908 during a period of industrial renaissance in the United States. https://www.thoughtco.com/timeline-of-exploration-1492-1585-104281 (accessed March 4, 2023). HMS Department of Neurobiology researchers provide the first molecular explanation for how the blood-brain barrier remains closedby suppressing the process for transporting molecules across cells in vesicles, or small bubbles. In 2008, NASA's Mars Phoenix lander touched down on the planet to try and find signs of water. John Davis devised the handier backstaff. A Timeline of North American Exploration: 1492-1585. This article discounts mere speculation as discovery, although imperfect reasoned arguments, arguments based on elegance/simplicity, and numerically/experimentally verified conjectures qualify (as otherwise no scientific discovery before the late 19th century would count). All rights reserved. This website helped me pass! The citation above will include either 2 or 3 dates. Matteo arrives in Goa to study and teach theology. X-rays are discovered by Wilhelm Conrad Roentgen in 1895, Germany. Their technique also leads to vaccines against measles, mumps, rubella and chickenpox. 5th century BC: The Greeks start experimenting with straightedge-and-compass constructions. Ten sample tubes, capturing an amazing variety of Martian geology, have been . He is an adjunct history professor, middle school history teacher, and freelance writer. c 150 BC Aglaonike, a woman astronomer lives 130-210 AD The doctor Galen lives. Mass General radiologists pioneer the use of MRI, or magnetic resonance imaging, to diagnose illness and injury. The Great stupa of Borobudur in Java was created. He was one of the first to realize that the region was, in fact, a new continent and not the Eastern part of Asia. Mass General researchers pioneer the positron emission tomography (PET) scan, an imaging technique that made possible one of the first noninvasive looks at functional changes within the brain and other organs. The Portuguese opened a new Eastern waterway to India around the tip of Africa. succeed. Discovery of Silicon. They did, however, establish a colony on Manhattan Island in the early 1600s and conducted explorations throughout the Caribbean. Black holes Laplace predicts the existence of black holes May 18, 1754 . Retrieved from https://www.thoughtco.com/timeline-of-exploration-1492-1585-104281. ThoughtCo, Feb. 16, 2021, thoughtco.com/timeline-of-exploration-1492-1585-104281. Spearheaded by faculty in the HMS Department of Global Health and Social Medicine, a report by The Lancet Commission on Global Surgery reveals that 5 billion people are unable to access safe, timely and affordable surgery, leading to 18.6 million preventable deaths each year worldwide. It began with the Vikings' brief stint . the sum of consecutive integers), by the Pythagoreans. Ed. Fresnel lenses. Egyptians began to use the civil year or Nile year. Watch on. 1936: Seth Neddermeyer, with Carl Anderson, discovered the muon, a negatively charged subatomic particle. Eliot Cutler performs the worlds first successful heart valve surgery at the Peter Bent Brigham Hospital, today part of Brigham and Womens Hospital. From that area, Eannes brought back the first human cargo-two hundred Africans to be sold as slaves in Lagos. It first focuses on the contributions of Michael Faraday in the nineteenth century and ends with the work of Ernest Rutherford and Albert Einstein in the early twentieth century. 25 Shattuck Street
As a member, you'll also get unlimited access to over 88,000 eNotes Editorial. 1675 - More than 3000 coffeehouses in England. An HMS Genetics team, led by Stephen Elledge, uses a technique called RNA interference (RNAi) to dial down the production of thousands of proteins and determine which are required for cancer cells to survive, exposing a hidden set of drug targets for possible new cancer therapies. Captain Magnus Andersen made a 28-day passage from Bergen to Newfoundland through a stormy sea in an exact replica of the Gkstad ship. Age of Exploration Timeline 1500s-1800s. 1519: Spanish conquistador and cartographerAlonso lvarez de Pineda (14941520) sails from Florida to Mexico, mapping the gulf coast along the way and landing in Texas. There is also a survey of mathematics, which highlights the contributions of Father Marin Mersenne and Sir Isaac Newton. In a first, the newly developed Drinker Respirator (iron lung) saves a polio patient at Peter Bent Brigham in collaboration with Children's Hospital Medical Center, today Boston Childrens Hospital, and the Harvard School of Public Health. Research conducted in resource-limited nations by the HMS Department of Social Medicine, now Global Health and Social Medicine, provides the first hard evidence that people infected with multidrug-resistant tuberculosis can be treated successfully by developing community-based outpatient treatment models. ", Columbus and Later Explorations (14921519). McLean researchers identify four types of brain abnormalities associated with abuse and neglect experienced in childhood. Traditionally, the age of exploration in America begins in 1492 with the first voyage of Christopher Columbus. 10th century AD: Manjula in India discovers the derivative, deducing that the derivative of the sine function is the cosine. Caesar burned the famous library of Alexandria. In 1845, just one year before the first successful surgery with anesthesia, Morton and Wells had been experimenting with nitrous oxide ("laughing gas"). 1539: French Franciscan friar Fray Marcos de Niza (14951558), sent by the Spanish governor of Mexico (New Spain), explores Arizona and New Mexico searching for the Seven Cities of Gold and foments rumor-mongering in Mexico City that he has seen the cities when he returns. Learn more about research at HMS on the Quad and beyond. ~250 BCE. 1699 - First cultivation in Java (Indonesia). The beginning and ending of the era are subject to debate, but most everyone agrees the Age of Discovery peaked throughout the 1500s. Birthdate: June 8, 1955. 1 Since then, our understanding of autism has evolved, culminating in the current diagnosis of autism spectrum disorder (ASD) and . 2023
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