2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Applies only to oral form of both agents. Use Caution/Monitor. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Slowing the infusion rate may alleviate symptoms. US residents can call their local poison control center at 1-800-222-1222. May increase risk of hypotension. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Avoid or Use Alternate Drug. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Crown Rump Length and Nuchal Translucency. We'll do this entirely for free, as long as the calculator has applications for women's health. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Accessed: 4/12/2011. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Your doctor will do laboratory tests to monitor your response. MISSED DOSE: It is important to get each dose of this medication as scheduled. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Hollands J, Foote E, Rodriguez A. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Applies only to oral form of both agents. It is unlikely . Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. 1988 May;111(5):566-70. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Applies only to oral form of both agents. IDA diagnosis is based on full blood examination and on the serum ferritin level. Use Caution/Monitor. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Applies only to oral form of both agents. Use Caution/Monitor. Minor (1)iron sucrose, benazepril. This calculator will help pinpoint potential causes of anemia based on Administer Venofer early during the dialysis session (generally within the first hour). For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Minor/Significance Unknown. Minor/Significance Unknown. Venofer treatment may be repeated if necessary. STORAGE: Consult the product instructions and your pharmacist for storage details. Avoid or Use Alternate Drug. All Rights Reserved. Minor/Significance Unknown. This topic . Applies only to oral form of both agents. https://www.uptodate.com/ (Requires subscription). View the formulary and any restrictions for each plan. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Applies only to oral form of both agents. Use Caution/Monitor. J Lab Clin Med. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. This cost includes the fee charged by the pharmacy. Use Caution/Monitor. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. 2000 Jan;22(1):39-43. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. 1. Use alternatives if available. Applies only to oral form of both agents. This site complies with the HONcode standard for trust- worthy health information: verify here. Parenteral iron dextran therapy. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. No additional iron to replenish stores. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Intravenous iron-dextran: therapeutic and experimental possibilities. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. 4. The dosage of Venofer is expressed in mg of elemental iron. Assure stable intravenous access to avoid extravasation. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Drug Des Devel Ther; 5: 5160. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Use Caution/Monitor. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Avoid or Use Alternate Drug. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Corrected Sodium and Effective Osmolality. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Applies only to oral form of both agents. Step 2: Calculation and administration of the maximum individual iron dose(s): . iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Canada residents can call a provincial poison control center. Minor/Significance Unknown. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Venofer treatment may be repeated if necessary. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Copyright 1993-2021 Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Applies only to oral form of both agents. Use Caution/Monitor. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Kumpf VJ. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Your doctor will do laboratory tests to monitor your response. 2. Avoid or Use Alternate Drug. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Applies only to oral form of both agents. Dosing: (a) Divide calculated total cumulate dose . Keep all medical and lab appointments. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Venofer has not been studied in patients younger than 2 years old. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. https://www.uptodate.com/ (Requires subscription). Each mL contains 20 mg of elemental iron. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Administer on 5 different occasions over a 14 day period. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Applies only to oral form of both agents. Use Caution/Monitor. By using this form you agree with the storage and handling of your data by this website. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Due Date form Ultrasound Report. Applies only to oral form of both agents. iron sucrose, benazepril. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. All Rights Reserved. Minor/Significance Unknown. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Each mL contains 20 mg of elemental iron. Last updated 28/06/2018 Enter values here and press 'Calculate'. Avoid or Use Alternate Drug. 2015: 763576. Medicinal forms Use Caution/Monitor. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Modify Therapy/Monitor Closely. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Separate dosing of tetracyclines from these products. Use Caution/Monitor. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Uses for Iron Sucrose IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Nutr Clin Pract. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Comparable efficacy to that of IV iron sucrose. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. The dosage of Venofer is expressed in mg of elemental iron. Please confirm that you would like to log out of Medscape. 5. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Applies only to oral form of both agents. Schweiz Med Wochenschr. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Use Caution/Monitor. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Max Dose. Administer while the patient is in a reclined or semi-reclined position. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. 1982;13(4):309-21. This site contains information for licensed healthcare professionals in the United States. Steps on how to print your input & results: 1. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. iron sucrose increases levels of calcium acetate by enhancing GI absorption. This drug is available at a higher level co-pay. World J Gastroenterol; 16(22): 27202725. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Administer a test INFeD dose prior to the first therapeutic dose. Chandler G, Harchowel J, Macdougall I. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. 1 ,*. Schrier SL, Mentzer WC, Landaw SA. Manage and view all your plans together even plans in different states. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Do not double the dose to catch up. Use Caution/Monitor. Ferritin and transferrin are also recommended monitoring . HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Applies only to oral form of both agents. Applies only to oral form of both agents. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For liquid medications, also enter the value of the Medicine Concentration and choose . Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration.

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