Suggested citation for this article: Taylor CA, Whitaker M, Anglin O, et al. This was the highest age-adjusted weekly rate observed among any racial and ethnic group during the pandemic. Vaccination status (unvaccinated, receipt of a primary series only, or receipt of a primary series plus a booster or additional dose) was determined for individual hospitalized patients and for the catchment population using state immunization information systems data (2). On 13 December, Denmark released data showing that hospitalization rates for people infected with Omicron seemed to be on a par with those for people infected with other variants. Slider with three articles shown per slide. These persons are excluded from the proportions of race/ethnicity but are included in other analyses. 189, 13791388 (2020). SARS-CoV-2 variant data update, England: Version 21. Wkly Rep. 71, 352358 (2022). The average age of decedents was 83.3 years. Infections are rare and can be severe or fatal, but so far scientists don't see genetic changes that pose an increased threat to people. Monthly incidence is based on SARS-CoV-2 positive test result date or, if not known, hospital admission date. Lipkind, H. S. et al. CAS Over the entire study period, the crude rate of hospitalization with a SARS-CoV-2 positive test was lower during the first 6 months of life among infants whose mothers received at least two doses . Nature. 20, 15225 (2016). Rep. 7, 255263 (2022). * Overall rates are unadjusted; rates presented by racial and ethnic group are age-adjusted. No other exclusion criteria were applied. Hospitalization rates among non-Hispanic Black adults increased more than rates in other racial/ethnic groups. Risk of hospitalisation associated with infection with SARS-CoV-2 lineage B.1.1.7 in Denmark: an observational cohort study. Foppa, I. M., Haber, M., Ferdinands, J. M. & Shay, D. K. The case test-negative design for studies of the effectiveness of influenza vaccine. N. Engl. Over the entire study period, the crude rate of hospitalization with a SARS-CoV-2 positive test was lower during the first 6 months of life among infants whose mothers received at least two doses of mRNA COVID-19 vaccines during pregnancy compared with infants whose mothers were unvaccinated during pregnancy (21/100,000 PY vs. 100/100,000 PY). PubMed pdf files, Omicron: fewer adverse outcomes come with new dangers, Statement on offensive historical content, Redistribute or republish the final article, Reuse portions or extracts from the article in other works. https://doi.org/10.1038/s41467-023-36547-4, DOI: https://doi.org/10.1038/s41467-023-36547-4. To ensure stability and reliability of rates by vaccination status, data are presented beginning 14 days after at least 5% of the age group-specific population of the COVID-NET surveillance catchment area has received an additional or booster dose. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Internet Explorer). Mortal. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Sign up for notifications from Insider! Dis. 182, 825831 (2022). O.Z. Adults with no documented receipt of any COVID-19 vaccine dose before the test date were considered unvaccinated. We thank staff at UKHSA and members of the UK Government SPI-M committee and the UKHSA Variant Technical Group for valuable discussions. During the Delta period, we found that protection extended through the infants first 6 months of life. Morb. In January 2022, unvaccinated adults and those vaccinated with a primary series, but no booster or additional dose, were 12 and three times as likely to be hospitalized, respectively, as were adults who received booster or additional doses. We use cookies to help provide and enhance our service and tailor content and ads. CAS Effectiveness of COVID-19 vaccines in preventing hospitalization among adults aged 65 yearsCOVID-NET, 13 states, FebruaryApril 2021. During the Omicron-predominant period, weekly COVID-19associated hospitalization rates (hospitalizations per 100,000 adults) peaked at 38.4, compared with 15.5 during Delta predominance. During the Delta dominant period, the crude incidences of testing positive for SARS-CoV-2 during the first 2, 4, and 6 months of life were lower among infants whose mothers received at least two doses of mRNA COVID-19 vaccines during pregnancy (0.75, 1.43, and 1.56 infants per 100 person-years [PY], respectively) than those whose mothers were not vaccinated during pregnancy (5.47, 5.10, and 4.78 infants per 100 PYs, respectively). MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services. Models were adjusted for the covariates listed above. Surveillance officers abstracted data on sampled patients from medical charts. What are the implications for public health practice? and B.F. P.R. 384, 22732282 (2021). COVID-19Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status COVID-NET, 14 States, July 2021January 2022. Our findings that receipt of at least two doses of COVID-19 vaccine during pregnancy was effective at protecting infants during the Delta period are similar to those reported in a recent Norwegian study showing that mRNA COVID-19 vaccination during pregnancy was associated with a 71% decreased risk of testing positive for SARS-CoV-2 in infants during their first 4 months of life during the Delta period17. During the Delta period, receipt of one dose during the third trimester reduced infants risk of testing positive for SARS-CoV-2 by 74% (95% CI: 19, 92) during the first 6 months of life (Table3). Relative to the Delta-predominant period, a larger proportion of hospitalized Black adults were unvaccinated. Despite several studies showing that vaccination during pregnancy is safe for pregnant people24,25,26,27,28, vaccine uptake has been suboptimal in this group29. Data requests may be sent to Kaiser Permanente Division of Research: DOR.IRB.Submissions@kp.org. Among children 12 to 17, the . Klein, N. P. et al. The proportion of hospitalized Black adults who received a primary COVID-19 vaccination series with or without a booster or additional dose increased from 4.7% and 14.9%, respectively, during the Delta-predominant period to 14.8% and 25.5%, respectively, during the Omicron-predominant period; Hispanic adults experienced smaller increases. Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. . All information these cookies collect is aggregated and therefore anonymous. Because the immune status of all patients is not known, an additional dose (recommended for persons with a weakened immune system) cannot be distinguished from a booster dose. The mean age at pregnancy onset was 31.62 years (standard deviation of 4.66 years). Article Science brief: omicron (B.1.1.529) variant. While this proportion might not be representative of the proportion of vaccinated pregnant women within KPNC because of our exclusion criteria, more efforts are needed to promote COVID-19 vaccines for pregnant persons because vaccination provides protection to mothers and their infants until they are old enough to receive their own COVID-19 vaccines. Morb. Health and Human Services. Messer, L. C. et al. MB), Help with Infants were followed from birth until the first positive SARS-CoV-2 test by PCR at age 2, 4, or 6 months, with censoring due to death, health plan disenrollment, or end of follow-up (May 31, 2022). Thus, this design better adjusts for healthcare-seeking behavior31,32, but it may also introduce other biases including selection bias33. J. Pediatr. Office of the Vice President for Research, University of Minnesota, Minneapolis, MN, 2023 Regents of the University of Minnesota. Two new observational studies suggest that COVID-19 vaccination lowers long-COVID incidence and severity. Annually, approximately 40,000 births occur at KPNC facilities. Vaccine effectiveness of cell-culture relative to egg-based inactivated influenza vaccine during the 2017-18 influenza season. In all models, we used calendar days as the time scale to account for changes over time in SARS-CoV-2 circulation and vaccine uptake. Mortal. Persons who received no doses of any COVID-19 vaccine were considered unvaccinated. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Omicron data in UK is 'enormously worrying,' immunologist says "In the last two weeks, no fewer than 80% of admissions were below the age of 50 years. All HTML versions of MMWR articles are generated from final proofs through an automated process. Halasa, N. B. et al. 387, 227236 (2022). Risk factors for severe COVID-19 in children. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19COVID-NET, 13 states, March 1August 22, 2020. Adults who received booster doses were classified as those who completed the primary series and received an additional or booster dose on or after August 13, 2021, at any time after completion of the primary series, and 14 days before a positive test result for SARS-CoV-2, as COVID-19associated hospitalizations are a lagging indicator and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255). Risk was especially high for people with severe combined immunodeficiency (HR, 6.2). Morb. Hospitalisation associated with SARS-CoV-2 delta variant in Denmark. The funders played no direct role in the study. Evan J. Anderson reports grants from Pfizer, Merck, PaxVax, Micron, Sanofi-Pasteur, Janssen, MedImmune, and GlaxoSmithKline; personal fees from Pfizer, Medscape, Kentucky Bioprocessing, Inc., Sanofi-Pasteur, and Janssen, outside the submitted work; and institutional funding from the National Institutes of Health to conduct clinical trials of Moderna and Janssen COVID-19 vaccines. COVID-19 hospitalization rates per 100,000 population by age and vaccination status, January 05 to February 01, 2023 Age group Age-specific rate per 100,000 among unvaccinated individuals Age-specific rate per 100,000 among those who received at least one booster dose Likelihood of unvaccinated individuals being hospitalized with These data should be taken with a grain of salt. Atlanta, GA: US Department of Health and Human Services, CDC; 2022. Between December 15, 2020, and May 31, 2022, we identified 62,117 infants born at Kaiser Permanente Northern California (KPNC), an integrated healthcare delivery organization. Stock, Jade Carruthers, Rachael Wood, Joshua Guedalia, Michal Lipschuetz, Ofer Beharier, Tobias Homan, Sara Mazzilli, Domenico Martinelli, Manaf AlQahtani, Xing Du, Siddhartha Mukherjee, Jussipekka Salo, Milla Hgg, Lauri Sksvuori, Hiam Chemaitelly, Houssein H. Ayoub, Laith J. Abu-Raddad, Nature Communications 45 C.F.R. Ann Intern Med 2021;174:140919. provided as a service to MMWR readers and do not constitute or imply Omicron vaccine effectiveness estimates for 7 to 59 days, 60 to 119 days, and 240 days or more after the second dose are not presented owing to imprecision in the estimates and wide 95% CIs (ie, 100 percentage points). In the first study, a team led by US Centers for Disease Control and Prevention (CDC) researchers analyzed data on 192,509 hospitalizations from more than 250 hospitals in 13 states participating in the COVID-19Associated Hospitalization Surveillance Network from Jan 1, 2021, to Apr 30, 2022. You will be subject to the destination website's privacy policy when you follow the link. Requests for access to the underlying source data should be directed to UKHSA. The objective of this study was to further evaluate the effectiveness of at least two doses of mRNA COVID-19 vaccination during pregnancy for preventing SARS-CoV-2 infection in infants during the first 2, 4, and 6 months of life during the Delta and Omicron variant periods. National influenza and COVID-19 surveillance report: 27 January 2022 (week 4). NEW YORK and MAINZ, GERMANY, March 1, 2023 Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today submitted an application to the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) of a booster (fourth) dose of the companies' Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine in children 6 months through 4 years of age (also referred to as under 5 years). BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting. N. Engl. While Omicron caused a big spike in COVID-19 cases, vaccinated people continued to be less likely to be hospitalized than the unvaccinated. Buchan, S. A. et al. Pediatr. Proportions between the pre-Delta and Delta period were compared using chi-square tests; p-values <0.05 were considered statistically significant, adjusted for multiple comparisons using the Bonferroni correction method. Baden, L. R. et al. The increase in transmissibility of the Omicron variant might have amplified these risks for hospitalization, resulting in increased hospitalization rates among Black adults compared with White adults, irrespective of vaccination status. J. Med. During the study period, the omicron variant experienced a rapidly increasing incidence, whereas the delta variant was experiencing a decreasing or less rapidly increasing incidence. *** An additional 172 (3.4%, 95% CI = 2.7%4.2%) adults were partially vaccinated, 69 (0.9%, 95% CI=0.61.2) received a primary vaccination series <14 days before receiving a positive SARS-CoV-2 test result, and 186 (4.1%) had unknown vaccination status; these groups are not further described in this analysis. During the period of Omicron predominance, hospitalization rates increased most sharply among Black adults in the United States relative to all other racial and ethnic groups examined and reached the highest rate observed among all racial and ethnic groups since the beginning of the pandemic. Receipt of COVID-19 vaccine during pregnancy and preterm or small-for-gestational-age at birtheight integrated Health Care Organizations, United States, December 15, 2020-July 22, 2021. PubMed Libby Reeg reports grants from the Michigan Department of Health and Human Services during the conduct of the study. TN, NMF, SB, EV, SRS, DDA, and AMP developed the methodology. Maternal vaccination and risk of hospitalization for Covid-19 among infants. During the study period, home testing became more prevalent. https://downloads.aap.org/AAP/PDF/AAP%20and%20CHA%20-%20Children%20and%20COVID-19%20State%20Data%20Report%209.29.22%20FINAL.pdf?_ga=2.255000394.335550773.1665001859-370326403.1636740765 (2022). and/or the original MMWR paper copy for printable versions of official text, figures, and tables. The KPNC Institutional review board approved and waived consent for this study. These findings are consistent with estimates of booster effectiveness against symptomatic Omicron infection using healthcare ascertainment. Rep. 69, 10811088 (2020). The outcomes were the infants first positive nasal/throat swab for SARS-CoV-2 by PCR, and the first COVID-19-related hospitalization, occurring during the first 6 months of life and recorded in the electronic health record.

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